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Recurrent deep venous thrombosis caused by congenital interruption of the inferior vena cava and heterozygous factor V Leiden mutation
Author(s) -
Schneider J. G.,
Eynatten M. V.,
Dugi K. A.,
Duex M.,
Nawroth P. P.
Publication year - 2002
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.2002.01034.x
Subject(s) - medicine , inferior vena cava , thrombosis , venous thrombosis , dysgenesis , factor v leiden , factor v , vascular malformation , surgery , radiology , anatomy
. Schneider JG, Eynatten MV, Dugi KA, Duex M, Nawroth PP (Ruprecht‐Karls‐University of Heidelberg, Heidelberg, Germany). Recurrent deep venous thrombosis caused by congenital interruption of the inferior vena cava and heterozygous factor V Leiden mutation (Case report). J Intern Med 2002; 252: 276–280. A case of a 44‐year‐old patient with recurrent deep venous thrombosis (DVT) caused by congenital dysgenesis of the inferior vena cava (IVC) in coincidence with heterozygous factor V Leiden mutation is presented. The IVC malformation was a fortuitous finding because the vascular malformation of the collateral draining thoracic veins were suspected to be a malignant mass in chest X‐ray. This vascular abnormality is a rare finding but recent epidemiological research suggests that there may be an association between the congenital absence of the IVC and DVT. In our case, the patient is even at higher risk combining the malformation probably affecting venous blood flow and the hypercoagulabilic state by heterozygous presence of the factor V Leidenmutation.