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Prospects for chemoprevention of cancer
Author(s) -
TAMIMI R. M.,
LAGIOU P.,
ADAMI H.O.,
TRICHOPOULOS D.
Publication year - 2002
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.2002.00969.x
Subject(s) - medicine , cancer , cancer prevention , public health , gerontology , family medicine , pathology
Tamimi RM, Lagiou P, Adami H‐O, Trichopoulos D (Harvard School of Public Health, Boston, MA, USA; University of Athens Medical School, Goudi, Athens, Greece; and Karolinska Institute, University of Stockholm, Stockholm, Sweden). Prospects for chemoprevention of cancer (Review). J Intern Med 2002; 251: 286–300. The recent progress in molecular biology and pharmacology has increased the likelihood that cancer prevention will rely increasingly on interventions collectively termed `chemoprevention'. Cancer chemoprevention is the use of agents to inhibit, delay or reverse carcinogenesis. A number of potential targets for chemoprevention have recently been identified. Many classes of agents including antioestrogens, anti‐inflammatories, antioxidants and other diet‐derived agents have shown a great deal of promise. In this review, we will begin by describing the general classes of chemopreventive agents and the mechanisms by which these agents act. We will then describe the opportunities that presently exist for chemoprevention of specific cancers.