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Specific bronchoalveolar lavage fluid T cells associate with disease in a pair of monozygotic twins discordant for sarcoidosis
Author(s) -
Grunewald J.,
Eklund A.
Publication year - 2001
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.2001.00916.x
Subject(s) - bronchoalveolar lavage , sarcoidosis , medicine , monozygotic twin , immunology , pathology , lung , biology , genetics
. Grunewald J, Eklund A (Karolinska Hospital, Stockholm, Sweden). Specific bronchoalveolar lavage fluid T cells associate with disease in a pair of monozygotic twins discordant for sarcoidosis (Case report). J Intern Med 2001; 250: 535–539. A 49‐year‐old Caucasian woman had an acute onset of sarcoidosis. Bronchoscopy with bronchoalveolar lavage (BAL) showed a pronounced accumulation of BAL fluid CD4 + T cells expressing the T‐cell receptor (TCR) AV2S3 gene. In line with this observation, the patient was HLA‐DR17 positive, previously shown to strongly correlate with lung compartmentalized AV2S3 + T cells. At follow‐up after recovery, reduced numbers of BAL fluid AV2S3 + T cells were found. Interestingly, BAL fluid of a healthy monozygotic twin sister contained normal numbers of AV2S3 + lung T cells. This report shows the T‐cell repertoire of BAL fluid T cells to correlate with the disease (sarcoidosis), indicating a local and specific immune response triggered by an unknown antigen in sarcoidosis.