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A case of POEMS syndrome with high concentrations of interleukin‐6 in pericardial fluid
Author(s) -
Shikama N.,
Isono A.,
Otsuka Y.,
Terano T.,
Hirai A.
Publication year - 2001
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.2001.00863.x
Subject(s) - poems syndrome , organomegaly , medicine , plasma cell dyscrasia , pericardial fluid , pathogenesis , pericardial effusion , polyneuropathy , pericarditis , proinflammatory cytokine , pathology , immunology , inflammation , antibody , immunoglobulin light chain
. Shikama N, Isono A, Otsuka Y, Terano T, Hirai A (Department of Internal Medicine, Chiba Municipal Hospital; and Second Department of Internal Medicine, Chiba University School of Medicine, Chiba, Japan). A case of POEMS syndrome with high concentrations of interleukin‐6 in pericardial fluid. J Intern Med 2001; 250: 170–173. The POEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy of various forms, monoclonal gammopathy, skin changes) is a rare multisystem disorder of unknown pathogenesis. Overexpression of proinflammatory cytokines has been implicated in the pathogenesis of POEMS syndrome, however, it is not known whether there is an association between abnormalities in cytokines and pericardial fluid. We present a case of POEMS syndrome with high concentrations of interleukin‐6 (IL‐6) in pericardial fluid. In our patient, pericarditis developed into cardiac tamponade, and the concentration of IL‐6 in pericardial fluid was remarkably elevated compared with that in serum (1760 vs. 6.57 pg mL –1 ). We suggest that IL‐6 is associated with the progression or maintenance of pericarditis as a result of POEMS syndrome.