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A case of toxic shock‐like syndrome presenting with serious hypoproteinaemia because of a protein‐losing gastroenteropathy
Author(s) -
Tasaki K.,
Sasaki M.,
Bamba M.,
Shintani Y.,
Andoh A.,
Tsujikawa T.,
Koyama S.,
Fujiyama Y.,
Bamba T.
Publication year - 2001
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.2001.00857.x
Subject(s) - lamina propria , medicine , pathogenesis , hyperplasia , infiltration (hvac) , toxic shock syndrome , pathology , immunohistochemistry , cytotoxic t cell , atrophy , biopsy , cd8 , immunology , shock (circulatory) , immune system , biology , bacteria , epithelium , biochemistry , physics , genetics , in vitro , thermodynamics , staphylococcus aureus
. Tasaki K, Sasaki M, Bamba M, Shintani Y, Andoh A, Tsujikawa T, Koyama S, Fujiyama Y, Bamba T (Shiga University of Medical Science, Shiga, Japan). A case of toxic shock‐like syndrome presenting with serious hypoproteinaemia because of a protein‐losing gastroenteropathy (Case report). J Intern Med 2001; 250: 174–179. A 37‐year‐old man was admitted to our hospital because of toxic shock‐like syndrome (TSLS) induced by Streptococcus pyogenes . After the pathogenic bacteria had been eradicated, serious diarrhoea appeared and a protein‐losing gastroenteropathy developed. An immunohistochemical study of the biopsy specimens of both small and large intestines revealed the infiltration of T‐lymphocytes, predominantly CD8+ cells, into the lamina propria of affected mucosa, villus atrophy and crypt hyperplasia. Considering these histological findings, some immunological mechanism which lead the activation of cytotoxic T‐lymphocytes may play an important role in the pathogenesis of this rare intestinal manifestation of TSLS.