Premium
Consumption of French‐press coffee raises cholesteryl ester transfer protein activity levels before LDL cholesterol in normolipidaemic subjects
Author(s) -
De Roos B.,
Van Tol A.,
Urgert R.,
Scheek L. M.,
Van Gent T.,
Buytenhek R.,
Princen H. M. G.,
Katan M. B.
Publication year - 2000
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.2000.00728.x
Subject(s) - cholesterylester transfer protein , phospholipid transfer protein , endocrinology , medicine , cholesterol , sterol o acyltransferase , lecithin , cholesteryl ester , phospholipid , lipoprotein , chemistry , biochemistry , membrane
. de Roos B, van Tol A, Urgert R, Scheek LM, van Gent T, Buytenhek R, Princen HMG, Katan MB (Wageningen University; Erasmus University, Rotterdam; and Gaubius Laboratory, Leiden; Wageningen Centre for Food Sciences, The Netherlands). Consumption of French‐press coffee raises cholesteryl ester transfer protein activity levels before LDL cholesterol in normolipidaemic subjects. J Intern Med 2000; 248: 211–216. Objectives. To determine the long‐term effects of unfiltered coffee consumption on the activity levels of cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP) and lecithin:cholesterol acyltransferase (LCAT) and to assess a possible role of CETP activity levels in the rise in serum LDL cholesterol. Subjects and design. Forty‐six healthy normolipidaemic subjects consumed 0.9 L of either French‐press or filtered coffee for 24 weeks. Fasting blood samples were obtained after 0, 2, 12 and 24 weeks of intervention and after and 12 weeks of follow‐up. Main outcome measures. Serum activity levels of CETP, PLTP and LCAT. Results. Relative to baseline, French‐press coffee significantly increased average CETP activity by 12% after 2 weeks, by 18% after 12 weeks, and by 9% after 24 weeks. PLTP activity was significantly increased by 10% after 12 and 24 weeks. LCAT activity was significantly decreased by 6% after 12 weeks and by 7% after 24 weeks. The increase in CETP clearly preceded the increase in LDL cholesterol, but not the increase in total triglycerides. However, consumption of French‐press coffee caused a persistent rise in CETP activity, whereas the rise in serum triglycerides was transient. Conclusions. Consumption of cafestol and kahweol cause a long‐term increase in CETP as well as PLTP activity; the increase in CETP activity may contribute to the rise in LDL cholesterol.