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Association of coronary heart disease with age‐adjusted aortocoronary calcification in patients with familial hypercholesterolaemia
Author(s) -
Jensen J. M.,
Gerdes L. U.,
Jensen H. K.,
Christiansen T. M.,
BrorholtPetersen J. U.,
Faergeman O.
Publication year - 2000
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.2000.00630.x
Subject(s) - medicine , framingham risk score , cardiology , cohort , coronary heart disease , calcification , coronary calcium score , body mass index , coronary arteries , cholesterol , calcinosis , disease , artery
. Jensen JM, Gerdes LU, Jensen HK, Christiansen TM, Brorholt‐Petersen JU, Faergeman O (Aarhus Amtssygehus University Hospital, Aarhus, Denmark). Association of coronary heart disease with age‐adjusted aortocoronary calcification in patients with familial hypercholesterolaemia. J Intern Med 2000; 247: 479–484. Objectives. Existing algorithms of risk of coronary heart disease (CHD) do not pertain to patients with familial hypercholesterolaemia (FH), whose arteries have been exposed to hypercholesterolaemia since birth. We studied a cohort of FH patients to compare four diagnostic models of CHD: traditional risk factors of CHD (age, sex, cholesterol, hypertension, smoking and body mass index), cholesterol year score, and aortic as well as coronary calcium measured by spiral computed tomography (CT). Subjects. We invited 88 individuals with molecularly defined FH of whom 80 (91%) decided to participate. Results. Analysis of receiver operating characteristic curves showed that the age‐adjusted coronary calcium score was more strongly associated with clinical manifestations of CHD than were traditional risk factors ( P < 0.002), cholesterol year score ( P << 0.0001), and the age‐adjusted aortic calcium score ( P < 0.0004). Conclusions. Age‐adjusted coronary calcium score shows promise as an indicator of CHD in FH patients.