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Fatal hepatitis and renal failure during treatment with nimesulide
Author(s) -
Schattner A.,
Sokolovskaya N.,
Cohen J.
Publication year - 2000
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.2000.00612.x
Subject(s) - medicine , nimesulide , jaundice , nephrotoxicity , acute tubular necrosis , coagulopathy , gastroenterology , acute kidney injury , hepatitis , sepsis , cholestasis , surgery , kidney
. Schattner A, Sokolovskaya N, Cohen J (Kaplan Medical Center, Rehovot, and the Hebrew University‐Hadassah School of Medicine, Jerusalem, Israel). Fatal hepatitis and renal failure during treatment with nimesulide (Case Report). J Intern Med 2000; 247: 153–155. A healthy 70‐year‐old woman who took nimesulide for 5 days, presented 2 weeks later with jaundice for which no other cause was found. Laboratory evidence of coagulopathy, hypoalbuminaemia and hypoglycaemia were present on admission, and liver biopsy showed massive necrosis of hepatocytes and severe inflammatory infiltrate. Despite supportive and corticosteroid treatment, her jaundice deepened and progressive acute renal failure developed, characterized by a ‘prerenal’ profile changing into irreversible acute tubular necrosis pattern, coma, occult Gram‐negative sepsis and death. Although rare, nimesulide‐associated hepatotoxicity and nephrotoxicity may occur and should be recognized as early as possible, to ensure immediate drug withdrawal and treatment.