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Sickle cell‐like crisis and bone marrow necrosis associated with parvovirus B19 infection and heterozygosity for haemoglobins S and E
Author(s) -
Eichhorn R. F.,
Buurke E. J.,
Blok P.,
Berends M. J. H.,
Jansen C. L.
Publication year - 1999
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.1999.0445f.x
Subject(s) - medicine , parvovirus , bone marrow , loss of heterozygosity , necrosis , parvoviridae , pathology , sickle cell anemia , immunology , virus , gene , genetics , biology , disease , allele
. In the literature, heterozygosity for haemoglobins S and E is known as a clinically benign condition. Nevertheless, we present a case of double heterozygosity manifesting as an infarctive sickle cell‐like crisis with acute chest syndrome and reversible bone marrow necrosis. Importantly, these complications were associated with serologically documented parvovirus B19 infection. Reviewing the literature, this case emphasizes a specific role of parvovirus B19 as a precipitating cause. Furthermore, it demonstrates how important the consideration of haemoglobin disorders can be even outside of the historically known areas.