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Insulin‐like growth factor‐I lowers fasting and postprandial triglyceride levels without affecting chylomicron clearance in healthy men
Author(s) -
Bianda T.,
Zapf J.,
Froesch E. R.,
Schmid C.
Publication year - 1999
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.1999.00501.x
Subject(s) - medicine , endocrinology , postprandial , triglyceride , chylomicron , insulin , apolipoprotein b , lipoprotein , crossover study , body mass index , cholesterol , very low density lipoprotein , alternative medicine , pathology , placebo
. Bianda T, Zapf J, Froesch ER, Schmid C (University Hospital, Zürich, Switzerland). Insulin‐like growth factor‐I lowers fasting and postprandial triglyceride levels without affecting chylomicron clearance in healthy men. J Intern Med 1999; 245 : 455–462. Objectives. To study whether IGF‐I treatment alters the postprandial lipid and lipoprotein metabolism. Design. Randomized, crossover study. Setting. University Hospital, Zürich, Switzerland. Subjects. Seven young healthy male subjects (aged 27 ± 4 years, body mass index (BMI) 21.8 ± 1.7 kg m –2 ). Interventions. Each subject was studied two times at 2‐week intervals, treated with saline 0.9% (S) and IGF‐I (8 µg kg –1 h –1 ) by a continuous subcutaneous infusion. 60 h after the start of treatment a vitamin A loading test was performed after an overnight 12‐h fast. Main outcome measures. Glucose, insulin, total and free IGF‐I, FFA, triglycerides and retinyl palmitate, total cholesterol, HDL and LDL cholesterol, lipoprotein (a) and apolipoprotein B were measured in serum before and after the fatty meal. Results. Total IGF‐I levels rose from 29.0 ± 3.3 nmol L –1 to 113.3 ± 9.0 nmol L –1 ( P < 0.02) and free IGF‐I from 0.24 ± 0.05 to 1.08 ± 0.28 nmol L –1 ( P < 0.02) during IGF‐I treatment. IGF‐I administration reduced insulin concentrations by 50% ( P < 0.02), as assessed by the area under the curve. Serum triglyceride levels were significantly lower at baseline and after the fat load during IGF‐I treatment ( P < 0.02), whereas the retinyl palmitate concentrations in chylomicron and nonchylomicron lipoprotein fractions were similar during both treatment periods. Conclusions. IGF‐I treatment reduces the triglyceride levels most probably by decreasing insulin secretion and the production of VLDL particles, and possibly by increasing their turnover. IGF‐I treatment has no significant effect on the metabolism of intestine‐derived triglyceride‐rich lipoproteins after a high fat meal in healthy young men.