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Idiopathic oedema with increased cytokine production: a pathogenetic link?
Author(s) -
Ulrich Hoffmann,
Adriano Fontana,
Johann Steurer,
A Bollinger
Publication year - 1998
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.1998.00326.x
Subject(s) - medicine , cytokine , interleukin 6 , tumor necrosis factor alpha , immunology , interleukin , receptor , pathology
Hoffmann U, Fontana A, Steurer J, Bollinger a (University Hospital, Zurich, Switzerland). Idiopathic oedema with increased cytokine production: a pathogenetic link? (Case Report). J Intern Med 1998; 244 : 179–82. We describe four patients with idiopathic oedema and elevated cytokines. All patients shared increased serum concentrations of soluble interleukin‐2 receptors (sIL‐2R). In three patients tumour necrosis factor alpha (TNF‐alpha), gamma interferon (IFN‐gamma) and interleukin‐2 (IL‐2) were transiently elevated. There was no evidence for an underlying disease. Based on experimental and clinical data it is hypothesized that oedema formation in our patients is the consequence of cytokine induced alteration of endothelial cells.