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Pathology of MEN‐1: morphology, clinicopathologic correlations and tumour development
Author(s) -
Komminoth,
Heitz,
Klöppel
Publication year - 1998
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.1998.00274.x
Subject(s) - pathology , pancreas , multiple endocrine neoplasia , medicine , phenotype , lung , endocrine system , stomach , biology , gene , genetics , hormone
Komminoth P, Heitz PU, Klöppel G (University of Zürich, Switzerland; and University of Kiel, Germany). Pathology of MEN‐1: morphology, clinicopathologic correlations and tumour development (Minisymposium: MEN & VHL). J Intern Med 1998; 243 : 455–64. Multiple endocrine neoplasia type 1 (MEN‐1) is an inherited syndrome which is characterized by the occurrence of neoplastic lesions in the parathyroids, the pancreas, duodenum, anterior pituitary and, less commonly, also in the stomach, thymus and lung. Its genetic defect has recently been identified and appears to involve a new type of tumour suppressor gene called mu on chromosome 11q13. In this overview, we will summarize the morphological features of the MEN‐1 phenotype, discuss its clinicopathologic profile and prognosis and outline the recent findings on the molecular pathology of this syndrome.