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Liposuction in Dercum's disease: impact on haemostatic factors associated with cardiovascular disease and insulin sensitivity
Author(s) -
Erik Berntorp,
Kerstin Berntorp,
Håkan Brorson,
Kerstin Frick
Publication year - 1998
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.1998.00264.x
Subject(s) - medicine , liposuction , adipose tissue , insulin resistance , diabetes mellitus , gastroenterology , fibrinogen , surgery , insulin , plasminogen activator , fibrinolysis , endocrinology
Berntorp E, Berntorp K, Brorson H, Frick K (University of Lund, Malmö, Sweden). Liposuction in Dercum's disease: impact on haemostatic factors associated with cardiovascular disease and insulin sensitivity. J Intern Med 1998; 243 : 197–201. Objective To study the impact of adipose tissue removal by liposuction on factors associated with increased risk of cardiovascular atherosclerotic disease within the coagulation and fibrinolytic system and glucose metabolism. Design, setting and subjects Liposuction was performed in 53 patients with Dercum's disease. The levels of fibrinogen, von Willebrand factor antigen (VWF:Ag) and plasminogen activator inhibitor type 1 activity (PAI‐1) were measured preoperatively, and 2 weeks, 4 weeks and 3 months postoperatively. In a subsample of 10 patients, insulin sensitivity was determined before and 2–4 weeks after surgery using the 2‐h euglycaemic hyperinsulinaemic clamp technique. The study was performed as a single‐centre study. Main outcome measure Fibrinogen, PAI‐1 and VWF:Ag levels, and glucose uptake before and after removal of adipose tissue. Results Weight reduction was sustained throughout the follow‐up period with a mean decrease from 90.7 to 86.6 kg ( P < 0.0001). There was a slight increase in levels of coagulation factors 2 and 4 weeks postoperatively, probably in reaction to the surgical trauma. After 3 months the values had returned to preoperative levels except for PAI‐1, which still showed a slight increase ( P < 0.05). In the subsample of 10 patients, glucose uptake was improved ( P < 0.05) from a short‐term perspective after surgery. Conclusion Surgical removal of adipose tissue, without change in lifestyle, does not seem to improve the levels of coagulation and fibrinolytic factors associated with cardiovascular atherosclerotic disease, whereas glucose takeup may be facilitated and insulin sensitivity increases from a short‐term perspective.