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Muscle fibre composition and glycogen synthase activity in hypertension‐prone men
Author(s) -
T Endre,
Ingrid Mattiasson,
Göran Berglund,
Hulthén Ul
Publication year - 1998
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.1998.00257.x
Subject(s) - medicine , endocrinology , skeletal muscle , glycogen , glycogen synthase
Endre T, Mattiasson I, Berglund G, Hulthén UL (Malmö University Hospital, Lund University, Malmö; Sweden). Muscle fibre composition and glycogen synthase activity in hypertension‐prone men. J Intern Med 1998; 243 : 141–147. Objectives To study muscle fibre characteristics and glycogen synthase activity in relation to peripheral glucose disposal in skeletal muscle in hypertension‐prone men. Design The hyperinsuliemic euglycemic clamp method was used to calculate insulin sensitivity index (M/I). Muscle biopsies were performed for the analysis of slow‐twitch (ST) and fast twitch (FT, low insulin sensitivity and low capillarisation compared to ST fibres) muscle fibres, capillarisation (number of capillaries per fibre) and diffusional index (mean area per fibre divided by capillarisation) of muscle fibres, capillary density (capillaries mm −2 muscle fibre) and glycogen synthase activity. Subjects Thirty‐two young, healthy, normotensive men with a family history of hypertension (REL) were compared to 25 age‐matched men with no family history of hypertension (CON) and similar body mass index (BMI). Results REL had a lower M/I (P = 0.021), lower capillarisation (P = 0.04) and a tendency of a lower diffusional index of subgroup b of FT muscle fibres (P = 0.10) compared to CON. Glycogen synthase activity did not differ between the groups. Conclusions Men with a family history of hypertension have less capillaries per FTb fibre and greater diffusion distance from the capillary to the muscle cell compared to controls, which may be a contributory factor to the lower insulin sensitivity in the former group. However, additional investigations are needed to study the casuality in this association.