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Metabolic features of inflammatory bowel disease in a remission phase of the disease activity
Author(s) -
Esmeralda Capristo,
Geltrude Mingrone,
Giovanni Addolorato,
Alberto Greco,
Giovanni Gasbarrini
Publication year - 1998
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.1998.00254.x
Subject(s) - medicine , ulcerative colitis , gastroenterology , body mass index , anthropometry , inflammatory bowel disease , respiratory quotient , surgery , disease
Capristo E, Mingrone G, Addolorato G, Greco AV, Gasbarrini G (Sacred Heart Catholic University, Rome, Italy). Metabolic features of inflammatory bowel disease in a remission phase of the disease activity. J Intern Med 1998; 243 : 339–47. Objectives To evaluate the anthropometric and metabolic characteristics of patients with Crohn's disease (CD) and ulcerative colitis (UC), comparing both groups with healthy volunteers. Design A cross‐sectional study. Setting The Department of Internal Medicine, Catholic University Hospital, Rome, Italy. Subjects Thirty‐four patients with biopsy‐proven inflammatory bowel disease (18 CD; 16 UC) in clinical remission (SCDAI <3 and Powell–Tuck index <4) not receiving steroid therapy. Interventions All patients had a clinical examination. Main outcome measures Blood indicators of inflammation and nutritional status. Body composition was assessed by both anthropometry and bioimpedance and metabolic variables were measured by indirect calorimetry over a 60–90 min period. Results CD had a lower body weight than both controls (58.1 kg, range 41.5–71.0 vs. 66.4 kg, range 57.0–76.0; P < 0.001) and UC) 58.1 kg, range 41.5–71.0 vs. 69.6 kg, range 50.5–94.0; P < 0.001). Fat‐free mass (FFM) did not differ between the groups, whilst fat mass was significantly lower in CD than in UC ( P < 0.05) and controls ( P < 0.001). Normalizing the basal metabolic rate by FFM, a higher value was found in CD compared with UC (143 kJ kg −1 d– −1 , range 97.5–179 vs. 133 kJ kg −1 d −1 , range 123–148; P < 0.05) and control subject 143 kJ kg −1 d −1 , range 97.5–179 vs. 134 kJ kg −1 d −1 , range 122–162; P < 0.05). The nonprotein respiratory quotient was significantly lower in CD compared to UC 0.80, range 0.73–0.84 vs. 0.84, range 0.79–0.91; P < 0.01) and controls (0.80, range 0.73–0.84 vs. 0.83, range 0.81–0.87; P < 0.001), with a consequently higher lipid oxidation rate in CD. Conclusions CD subjects showed a decreased fat mass and enhanced utilization of lipids compared with UC and controls. These data could be explained by the larger intestinal involvement and considered as a contribution to lipid tissue wasting in CD.