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The activated immune system and the renin–angiotensin–aldosterone system in congestive heart failure
Author(s) -
Михаил Самсонов,
J Lopatin,
Gernot P. Tilz,
Erika Artner-Dworzak,
E L Nassonov,
V Yu Mareev,
Jury N. Belenkov,
Helmut Wächter,
Dietmar Fuchs
Publication year - 1998
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.1998.00240.x
Subject(s) - heart failure , medicine , aldosterone , renin–angiotensin system , endocrinology , angiotensin ii , radioimmunoassay , neopterin , angiotensin receptor , angiotensin converting enzyme , cardiology , plasma renin activity , receptor , blood pressure
Samsonov M, Lopatin J, Tilz G, Artner‐Dworzak E, Nassonov E, Mareev V, Belenkov J, Wachter H, Fuchs D, (Cardiology Research Centre, Moscow, Russia; University of Graz, and the University of Innsbruck, Austria). Activated immune system and the renin–angiotensin–aldosterone system in congestive heart failure. J Intern Med 1998; 243 : 93–98. Objects The aim of the study was to investigate a possible relationship between plasma renin activity, angiotensin II, serum levels of angiotensin‐converting enzyme, aldosterone and markers of immune activation in congestive heart failure (CHF). Patients and Methods Fifty‐three patients (50 male, three female, mean age 46 ± 16 years) with congestive heart failure were studied. Twenty‐eight patients had I or II NYHA class of CHF and 25 patients had III or IV NYHA class (NYHA class, mean ± SD : 2.3 ± 0.9). Serum neopterin concentration and hormones were measured by commercial radioimmunoassays. Serum soluble receptors of tumour necrosis factor and interleukin‐2 were determined by ELISA. Results All analytes significantly correlated with NYHA classes ( P < 0.05). There existed correlations between neopterin and angiotensin‐converting enzyme or aldosterone ( rs = 0.35 and rs = 0.36, P < 0.05). The soluble tumour necrosis factor receptor concentrations correlated with plasma renin activity ( rs = 0.38, P < 0.05). Conclusion The result of our study suggest that there exists some relationship between the renin–angiotensin–aldosterone system and immune activation in severe congestive heart failure, however, the associations found are rather weak.