Premium
Helicobacter pylori seropositivity is not associated with inflammatory parameters, lipid concentrations and degree of coronary artery disease
Author(s) -
J Regnström,
Stefan Jovinge,
Peter Båvenholm,
CarlGöran Ericsson,
Ulf dé Fairé,
Anders Hamsten,
Mai-Lis Hellénius,
Jan Nilsson,
Per Tornvall
Publication year - 1998
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.1998.00202.x
Subject(s) - medicine , helicobacter pylori , coronary artery disease , myocardial infarction , fibrinogen , gastroenterology , prospective cohort study , population , immunology , environmental health
Regnström J, Jovinge S, Båvenholm P, Ericssond C‐G, de Faire U, Hamsten A, Hellenius M‐L, Nilsson J, Tornvall P (Karolinska Hospital and Danderyd Hospital, Stockholm, Sweden). Helicobacter pylori seropositivity is not associated with inflammatory parameters, lipid concentrations and coronary artery disease. J Intern Med 1998; 243 : 109–13. Objectives To determine the prevalence of chronic infection with Helicobacter pylori (HP) in patients with established coronary artery disease (CAD) and in healthy controls. Furthermore, to investigate whether HP infection is associated with inflammatory parameters, lipid concentrations and degree and progression of CAD. Design A case–control study combined with a prospective angiographic study. Setting Stockholm Metropolitan Area, Sweden. Patients and methods A material consisting of 92 young men aged 40.9 ± 3.2 (mean ± SD) years, with previous myocardial infarction and documented coronary atherosclerosis, and 95 healthy sex‐matched controls, aged 43.2 ± 3.0 (mean ± SD) years, with similar socio‐economic status and ethnic background was analysed for the prevalence of HP seropositivity, plasma concentrations of the inflammatory parameters fibrinogen, tumour necrosis factor alpha and orosomucoid, and serum concentrations of lipids. The impact of HP seropositivity on degree and progression of CAD, as assessed by quantitative coronary angiography, was also determined. Results The study population of mainly Scandinavian origin had a low prevalence of HP seropositivity in comparison with previously published European populations. No significant increase in HP seropositivity was found in patients compared with controls (42.2 vs. 32.6%). Furthermore, HP infection was not associated with increased levels of inflammatory parameters, lipid concentrations or with degree of angiographically determined CAD at baseline, or progression of CAD and clinical events over 5 years. Conclusions HP infection is not associated with inflammatory parameters and lipid concentrations and could not be confirmed as a risk factor for CAD.