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Alteration of arterial distensibility in systemic sclerosis
Author(s) -
CONSTANS J.,
GOSSE P.,
PELLEGRIN J.L.,
ANSOBORLO P.,
LENG B.,
CLÉMENTY J.,
CONRI C
Publication year - 1997
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.1997.87110000.x
Subject(s) - medicine , ambulatory , cardiology , blood pressure , pulse pressure , ambulatory blood pressure , arterial stiffness , pulse (music) , electrical engineering , detector , engineering
Objectives. To evaluate the distensibility of large arteries in patients with systemic sclerosis (SSc). Design. Prospective case‐control study including unselected patients with SSc. Setting. One cardiology and two internal medicine units in a teaching hospital. Subjects. Eighteen patients with SSc and controls matched for age, sex, height, weight and 24‐h ambulatory blood pressure (BP). Intervention. The timing of Korotkoff's sounds ( QKD interval), a newly described noninvasive ambulatory method was used to measure arterial distensibility during 24 h. Main outcome measures . Two endpoints were used: QKD 100–60 (normalized for a heart rate of 100 beats min ‐1 and a systolic BP of 100 mmHg) and the slope of QKD against pulse pressure. Results. The patients with SSc had a lower slope of QKD against pulse pressure than the controls (median 0.55, range 0–1.21, versus 0.92, range 0.5–1.34, respectively; P =0.003), and a lower QKD 100–60 (medians/ranges respectively 191 [162–216] and 203 [169–231]; P =0.01). Conclusions. These results indicate that arterial distensibility of large arteries is decreased in SSc.