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Glucose and insulin levels in young subjects with different maternal histories of hypertension: The Hypertension in Pregnancy Offspring Study
Author(s) -
HIMMELMANN A.,
HIMMELMANN K.,
SVENSSON A.,
HANSSON L.
Publication year - 1997
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.1997.66890000.x
Subject(s) - offspring , medicine , endocrinology , pregnancy , insulin resistance , insulin , blood pressure , c peptide , carbohydrate metabolism , impaired glucose tolerance , biology , genetics
Objective: To analyse whether hypertension during pregnancy is associated with early signs of impaired glucose metabolism in the offspring. Design: Longitudinal study with a 5‐year follow‐up. Setting: University Hospital, Göteborg, Sweden. Main outcome measures: Fasting levels of glucose, insulin and C‐peptide. Subjects: Thirty‐six children were born to mothers with hypertension in pregnancy. The children were divided into two groups according to their mothers' blood pressure at follow‐up 7–12 years after pregnancy. Nineteen children had hypertensive mothers (HT), while 17 children had normotensive mothers at follow‐up (NT). A control group (C) comprised 16 children, who were born after normotensive pregnancies to mothers who remained normotensive. Results: Fasting plasma glucose was significantly higher in HT than in NT (5.2 vs. 4.9 mmol L −1 ; P < 0.05). In C fasting glucose was 5.1 mmol L −1 . The same trend was seen for fasting insulin in HT, NT and C, respectively (6.7 vs. 4.7 vs. 5.3 μU mL −1 ). The C‐peptide level was 1.61, 155 and 1.64 ng mL −1 , respectively. Calculated insulin resistance was 1.5 in HT, 1.0 in NT and 1.2 in C. Conclusions: It is suggested that hypertension during pregnancy may be associated with impaired glucose metabolism and elevated fasting glucose levels in the offspring during adolescence.