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Delayed hypersensitivity to flurbiprofen
Author(s) -
ROMANO A.,
PIETRANTONIO F.
Publication year - 1997
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.1997.64887000.x
Subject(s) - medicine , flurbiprofen , angioedema , maculopapular rash , hypersensitivity reaction , nonsteroidal , allergy , drug , anaphylaxis , dermatology , rash , delayed hypersensitivity , drug allergy , provocation test , aspirin , adverse drug reaction , immunology , anesthesia , pharmacology , immune system , pathology , alternative medicine
Immune‐mediated reactions to nonsteroidal antiinflammatory drugs (NSAIDs) are unusual, and true allergy to the drug flurbiprofen has never been documented. We observed a patient who developed a maculopapular rash 48 h after beginning oral therapy with this drug, and 2 days later, angioedema and hypotension. Patch tests with flurbiprofen were positive 48 and 72 h after application. The clinical and allergologic features of this case strongly suggest type IV hypersensitivity. Patch testing with NSAIDs is useful for confirming clinical diagnoses of delayed hypersensitivity to these drugs.