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Paracetamol‐induced cholestatic and granulomatous liver injuries
Author(s) -
LINDGREN A.,
ALDENBORG F.,
NORKRANS G.,
OLAISON L.,
OLSSON R.
Publication year - 1997
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.1997.117153000.x
Subject(s) - medicine , cholestasis , cirrhosis , drug reaction , hepatitis , acetaminophen , liver injury , population , cholestatic hepatitis , drug , gastroenterology , pharmacology , environmental health
Objective. To describe uncommon (previously unreported) types of adverse liver reactions to paracetamol Design. In addition to describing patients, with uncommon types of liver reactions to paracetamol, admitted to our hospitals, we surveyed all the liver reactions to paracetamol reported to the Swedish Adverse Drug Reactions Advisory Committee from 1973 to 1993. Setting. The Swedish population of 8 million inhabitants. Measurement. Extensive medical evaluation. Results. We found one case with a cholestatic liver reaction and one with granulomatous hepatitis. The reactions were probably idiosyncratic and took several months to disappear. Conclusion. In addition to the well‐known dose‐related toxic liver damage paracetamol may rarely cause non‐dose‐related severe, prolonged cholestasis or granulomatous hepatitis with cirrhosis.