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Hyaluronan turnover in relation to infection and sepsis
Author(s) -
BERG S.
Publication year - 1997
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.1997.00177.x
Subject(s) - sepsis , medicine , septic shock , organ dysfunction , shock (circulatory) , disease , intensive care , immunology , gastroenterology , intensive care medicine
. Berg S (University Hospital, Linköping, Sweden). Hyaluronan turnover in relation to infection and sepsis (Minisymposium: Hyaluronan). J Intern Med 1997; 242 : 73–7. Sepsis is a major clinical problem in intensive care. The mortality in septic shock is high, and predominantly due to cardiovascular collapse and multiple organ dysfunction. In sepsis high levels of circulating hyaluronan have been found, correlating to disease severity and prognosis. The reason behind the increased levels could be both decreased hepatic uptake and increased peripheral synthesis. Thus, plasma hyaluronan may be a clinically useful marker of hepatic dysfunction and possibly also an indicator of the increased inflammatory and reparative activity in different organs in septic conditions.