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Is serum hyaluronan a helpful tool in the management of patients with liver diseases?
Author(s) -
Lindqvist U.
Publication year - 1997
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.1997.00176.x
Subject(s) - medicine , cirrhosis , liver transplantation , hyaluronic acid , liver disease , alcoholic liver disease , fibrosis , gastroenterology , liver function tests , liver function , hepatitis , viral hepatitis , pathology , transplantation , anatomy
Lindqvist U (University Hospital, Uppsala, Sweden). Is serum hyaluronan a helpful tool in the management of patients with liver diseases? (Minisymposium: Hyaluronan). J Intern Med 1997; 242 : 67–71. The results of serial determinations of serum hyaluronan indicate a prognostic value in progressive liver damage. In primary biliary cirrhosis and in cirrhotic alcoholic liver diseases serum hyaluronan level discriminates between early and advanced disease. In alcoholic liver disease serum hyaluronan can be applied as assessment of haemodynamic changes. Serum hyaluronan is of use as a non‐invasive index of liver fibrosis in chronic viral hepatitis. A reversible defect in the hyaluronan receptor of the hepatic endothelial cells was suggested following studies on paracetamol‐induced acute liver damage. In liver transplantation, graft function can be predicted by determination of the venous effluent of hyaluronan.