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Clinical features in persons with a family history of diabetes compared to controls (The Second Generation Fredericia Study)
Author(s) -
VESTBO E.,
DAMSGAARD E. M.,
FRØLAND A.,
MOGENSEN C. E.
Publication year - 1996
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.1996.62886000.x
Subject(s) - medicine , diabetes mellitus , family history , offspring , blood pressure , endocrinology , population , cohort , pregnancy , environmental health , biology , genetics
Objective. To compare clinical and biochemical features in non‐diabetic persons with a family history of non‐insulin dependent diabetes mellitus (NIDDM) to non‐diabetic persons without a family history of diabetes. Design. Cross‐sectional study. Setting. Population‐based survey in Fredericia, Denmark. Subjects. Seven hundred and forty subjects, the second generation of an earlier defined cohort was examined. The median age was 48 (range 26–65) years. Of the 740 subjects 696 were non‐diabetic. Interventions. The subjects had a clinical examination. Main outcome measures . Known risk factors for development of diabetes and cardiovascular disease. Results. More offspring of diabetic persons had NIDDM (χ 2 =6.36, P <0.05). Non‐diabetic males with a family history of diabetes had a higher BMI, fasting blood glucose, and triglycerides compared to males without a family history of diabetes. Non‐diabetic females with a family history of diabetes had a higher BMI, fasting blood glucose, HbA 1C , diastolic blood pressure, and lower HDL‐cholesterol than female offspring of non‐diabetics. In a multiple regression model we found that non‐diabetic offspring of diabetic persons had higher fasting blood glucose and HbA 1C compared to offspring of non‐diabetic persons when adjusted for the independent variables age, BMI, WHR, and sex. Conclusion. Our results may indicate that the only inherited factors from NIDDM patients are plasma blood glucose, HbA 1C and increased BMI which may be an indication for later diabetes, whereas other cardiovascular risk factors may be inherited independently of diabetes but associated with BMI.