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Association of a balanced chromosomal translocation (4; 12)(q21.3; q15), affective disorder and autism
Author(s) -
Nasr A.,
Roy M.
Publication year - 2000
Publication title -
journal of intellectual disability research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 104
eISSN - 1365-2788
pISSN - 0964-2633
DOI - 10.1046/j.1365-2788.2000.00239.x
Subject(s) - autism , chromosomal translocation , intellectual disability , psychology , association (psychology) , depression (economics) , developmental disorder , psychiatry , genetics , biology , psychotherapist , macroeconomics , gene , economics
This case report describes a set of monozygotic twins with severe intellectual disability, autism and affective disorder with a balanced translocation between chromosomes 4 and 12. Their mother, who carries the same balanced translocation, had severe postnatal depression. The association between autism affective disorder and these chromosome break points has not been reported previously. The implications are discussed.