Premium
Age at onset of dementia and age of menopause in women with Down’s syndrome
Author(s) -
Cosgrave M. P.,
Tyrrell J.,
McCarron M.,
Gill M.,
Lawlor B. A.
Publication year - 1999
Publication title -
journal of intellectual disability research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 104
eISSN - 1365-2788
pISSN - 0964-2633
DOI - 10.1046/j.1365-2788.1999.00192.x
Subject(s) - menopause , dementia , down syndrome , medicine , population , ageing , risk factor , gerontology , pediatrics , psychology , disease , psychiatry , environmental health
Menstrual status and the age of menopause were investigated in 143 Irish females with Down’s syndrome (DS). The average age of menopause in 42 subjects (44.7 years) was younger than in the general population. The age at onset of dementia correlated with the age of menopause. This finding may be a manifestation of accelerated ageing in DS or point to oestrogen deficiency being an independent risk factor for the development of Alzheimer’s dementia in DS. The implications of this finding for possible treatments are discussed.