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Prader–Willi syndrome and psychotic symptoms: I. Case descriptions and genetic studies *
Author(s) -
Bouras N.,
Clarke D.,
Boer H.,
Webb T.,
Scott P.,
Frazer S.,
Vogels A.,
Borghgraef M.,
Curfs L. M. G.
Publication year - 1998
Publication title -
journal of intellectual disability research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 104
eISSN - 1365-2788
pISSN - 0964-2633
DOI - 10.1046/j.1365-2788.1998.4260440.x
Subject(s) - abnormality , psychology , uniparental disomy , chromosomal abnormality , psychosis , psychiatry , clinical psychology , pediatrics , medicine , genetics , chromosome , biology , karyotype , gene
Six people with Prader–Willi syndrome (PWS) who developed psychoses are described. Along with other literature reviewed in the present paper, the results imply an association between PWS and psychotic symptoms. Genetic studies were possible in five cases and SNRPN expression was examined in three cases. Maternal uniparental disomy and 15qllq13 deletions were found, demonstrating that psychotic symptoms are not associated with a single type of genetic abnormality.