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Intolerance to an extensively hydrolysed formula mistaken for postoperative diarrhoea in a child with neuroblastoma
Author(s) -
Ward E.,
Picton S.
Publication year - 2001
Publication title -
journal of human nutrition and dietetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.951
H-Index - 70
eISSN - 1365-277X
pISSN - 0952-3871
DOI - 10.1046/j.1365-277x.2001.00279.x
Subject(s) - medicine , neuroblastoma , colonoscopy , hydrolysate , surgery , diarrhea , pediatrics , gastroenterology , colorectal cancer , hydrolysis , biology , cell culture , biochemistry , chemistry , genetics , cancer
Background Persistent diarrhoea has recently been reported as a common problem following surgical resection for advanced abdominal neuroblastoma. Case study A 10‐month‐old child, who had previously had no nutritional problems whilst undergoing chemotherapy treatment for a stage IV neuroblastoma, developed severe diarrhoea following tumour resection. He required nutritional support and was commenced on a continuous overnight nasogastric feed of a non‐milk protein hydrolysate feed (MCT Pepdite 0‐2, S.H.S. International Ltd, UK) His diarrhoea persisted and it was assumed that this was a postoperative problem which in time would regress. Two months later the child was admitted with a rectal prolapse, and a colonoscopy and biopsy suggested allergic protocolitis. The diarrhoea resolved rapidly on stopping the feed. Conclusion Although he was never re‐challenged with the non‐milk protein hydrolysate, it appears that he had a rare intolerance to an extensively hydrolysed protein formula which was masked by the assumption that his diarrhoea was a postoperative problem.