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A pharmacokinetic study of flumequine in sea bass, Dicentrarchus labrax (L.), after a single intravascular injection
Author(s) -
Rigos G,
Tyrpenou A,
Nengas I,
Alexis M
Publication year - 2002
Publication title -
journal of fish diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.819
H-Index - 85
eISSN - 1365-2761
pISSN - 0140-7775
DOI - 10.1046/j.1365-2761.2002.00340.x
Subject(s) - dicentrarchus , flumequine , sea bass , pharmacokinetics , volume of distribution , biology , fish <actinopterygii> , fishery , pharmacology , antibiotics , biochemistry , enrofloxacin , ciprofloxacin
The pharmacokinetic properties of flumequine following a single intravascular injection (10 mg kg –1 fish) were studied in sea bass, Dicentrarchus labrax (L.), 120 g held at 18 °C. The absorption half life ( t 1/2α ) and the elimination half life ( t 1/2β ) of the drug were calculated to be 1.05 and 10.71 h, respectively. Tissue penetration of flumequine seemed to be moderate because both the apparent volume of distribution of the drug at steady‐state ( V d(ss) ) and the extensive apparent volume of the central compartment ( V c ) were found to be small (1.51 and 0.626 L kg –1 ). The mean residence time ( MRT ) was short (09.73 h) and the total clearance (CL T ) of the drug was rapid (0.156 L kg –1 h –1 ).