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Toll‐like receptors: their role in allergy and non‐allergic inflammatory disease
Author(s) -
Sabroe I.,
Parker L. C.,
Wilson A. G.,
Whyte M. K. B.,
Dower S. K.
Publication year - 2002
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1046/j.1365-2745.2002.01451.x
Subject(s) - immunology , receptor , allergy , inflammation , disease , allergic inflammation , immunotherapy , biology , pattern recognition receptor , immune system , toll like receptor , signalling , medicine , innate immune system , microbiology and biotechnology , genetics , pathology
Summary The human TLRs comprise an important and interesting group of receptors that regulate pathogen‐related responses, and play as yet uncharacterized roles in the amplication of sterile inflammation. Signalling through these receptors, which are powerfully coupled in gene transcription processes, has powerful immunostimulatory and immunomodulatory effects. Exploitation of TLR signalling will probably lead to novel effective therapies for allergic disease, in the first instance through more efficient mechanisms of immunotherapy. The likelihood of adverse consequences of such treatments, though possible, may be minimized by use of conjugated vaccines.