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Alternative venlafaxine kinetics in overdose
Author(s) -
Langford N. J.,
Martin U.,
Ruprah M.,
Ferner R. E.
Publication year - 2002
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1046/j.1365-2710.2002.00438.x
Subject(s) - cyp2d6 , venlafaxine , pharmacokinetics , pharmacology , toxicokinetics , medicine , cytochrome p450 , chemistry , metabolism , hippocampus , antidepressant
Summary The pharmacokinetics of venlafaxine in therapeutic doses is well established. It is metabolized by the cytochrome P450 enzymes including CYP2D6. The toxicokinetics in overdose is less well known. Case report: A 33‐year‐old Caucasian female who ingested 3·0 g venlafaxine, and 210 mg zolpidem. The patient remained symptomatic for the following 24 h. Plasma pharmacokinetic analysis demonstrated a prolonged elimination half‐life of venlafaxine, estimated to be 15·3 h. We postulate that the patient was a slow metabolizer of substrates for CYP2D6, an enzyme known to exhibit polymorphism.