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The single nucleotide polymorphism T1128C in the signal peptide of neuropeptide Y (NPY) was not identified in a Korean population
Author(s) -
Ding B.,
Bertilsson L.,
Wahlestedt C.
Publication year - 2002
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1046/j.1365-2710.2002.00409.x
Subject(s) - single nucleotide polymorphism , snp , neuropeptide y receptor , genotyping , pyrosequencing , snp genotyping , biology , genotype , population , genetics , polymorphism (computer science) , neuropeptide , gene , medicine , receptor , environmental health
Objective: A single nucleotide polymorphism (SNP) T1128C, which causes an amino acid change from leucine(7) to proline(7) in the signal peptide of neuropeptide Y (NPY), has been found to be associated with multiple clinical parameters or disease. However, this SNP was not identified in the Japanese population. We asked if this is also true in the Korean population. Methods: Genotyping was conducted by pyrosequencing, a newly developed real‐time high‐throughput SNP scoring technique. Results: All 242 Korean subjects showed T1128/T1128 genotype. Conclusions: The T1128C SNP does not appear to exist in this Korean population.