Premium
Leaching of diethylhexyl phthalate from polyvinyl chloride bags into intravenous etoposide solution
Author(s) -
Demoré B.,
Vigneron J.,
Perrin A.,
Hoffman M. A.,
Hoffman M.
Publication year - 2002
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1046/j.1365-2710.2002.00395.x
Subject(s) - phthalate , polyvinyl chloride , leaching (pedology) , chemistry , chromatography , sodium , etoposide , polyvinyl alcohol , nuclear chemistry , organic chemistry , medicine , surgery , environmental science , soil water , chemotherapy , soil science
Objective: To compare the release of diethylhexyl phthalate (DEHP) from polyvinyl chloride (PVC) bags from four different manufacturers into intravenous etoposide solutions. Method Etoposide solutions, 0·4 mg/mL, containing the vehicle polysorbate 80 were prepared in 5% dextrose or 0·9% sodium chloride injection PVC bags and stored at room temperature for 24 h. DEHP content was analysed by high‐performance liquid chromatography. Results Substantial amounts of DEHP (up to 20 μ g/mL at room temperature) leached into the etoposide solutions. However, no significant differences were found in the amounts of DEHP leached into the etoposide infusion solutions prepared using either 5% dextrose or 0·9% sodium chloride injection and stored in the four different containers. Conclusion To minimize patient exposure o DEHP, etoposide solutions should ideally be stored in a glass or polyolefin container.