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Severe toxic hepatitis associated with amoxycillin and clavulanic acid
Author(s) -
Ersoz G.,
Karasu Z.,
Yildiz C.,
Akarca U. S.,
Yuce G.,
Batur Y.
Publication year - 2001
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1046/j.1365-2710.2001.00341.x
Subject(s) - clavulanic acid , medicine , gastroenterology , cholestatic hepatitis , amoxicillin , hepatitis , purpura (gastropod) , toxic hepatitis , antibiotics , microbiology and biotechnology , biology , ecology
Toxic hepatitis secondary to amoxycillin–clavulanic acid is an infrequent clinical picture. Most of the cases are reported to have a benign course. We report two cases of severe hepatic failure following amoxycillin–clavulanic acid use. One of the cases had cholestatic features primarily, and the other had hepatocellular injury prominently. The first case had also findings of trombotic trombositic purpura and had a fatal course.