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An evaluation of the change in electrocardiographic P‐wave variables after acute caffeine ingestion in normal volunteers
Author(s) -
Caron M. F.,
Song J.,
Ammar R.,
Kluger J.,
White C. M.
Publication year - 2001
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1046/j.1365-2710.2001.00336.x
Subject(s) - caffeine , medicine , crossover study , placebo , ingestion , anesthesia , electrocardiography , analysis of variance , cardiology , alternative medicine , pathology
Background: Caffeine’s effect on supraventricular dysrhythmias is poorly understood, and establishing a marker to predict atrial fibrillation may help to explain supraventricular dysrhythmias caused by caffeine. Objective: To evaluate the effects of caffeine (mean 6·1 mg/kg) on maximum P‐wave duration and P‐wave dispersion in normal volunteers. Method: A randomised, double‐blind, placebo‐controlled, crossover study in 10 healthy volunteers at least 17 years of age at the University of Connecticut. Participants abstained from caffeinated products for at least 2 days before study initiation and were randomly allocated on different days to receive placebo or caffeine 400 mg. For each of the study phases, a baseline 12‐lead electrocardiogram (ECG) was performed and a subsequent 12‐lead ECG was performed 3 h after ingesting the study drug. Results: No significant changes were found within intra‐ or intergroup comparisons for any P‐wave variables measured. Conclusions: Single dose caffeine (400 mg) does not affect average P‐wave duration, maximum P‐wave duration or P‐wave dispersion in normal individuals.