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Stability of captopril in invert sugar solution
Author(s) -
Sam W. J.,
Ho P. C.
Publication year - 1998
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1046/j.1365-2710.1998.00190.x
Subject(s) - captopril , sugar , chemistry , chromatography , biochemistry , endocrinology , medicine , blood pressure
Objective:To assess the stability of captopril in different concentrations of invert sugar solution and to verify the hypothesis that the antioxidant effect of invert sugar can inhibit captopril's oxidative degradation. Method: Captopril 1 mg/ml formulations were prepared in 0% (Milli‐Q water), 1%, 10%, 30% and 85% w/v of invert sugar and stored at 5 °C. The formulations were sampled at intervals up to 30 days for assay of captopril using a stability‐indicating high‐performance liquid chromatographic method. Results: Captopril in formulations containing low concentrations (1%, 10%, 30% w/v) of invert sugar was significantly less stable than in the control formulation (captopril 1 mg/ml in Milli‐Q water). In contrast, captopril in a formulation containing 85% w/v invert sugar was substantially more stable than in the control. Conclusion: Captopril formulated in a solution of 85% w/v invert sugar is stable for at least 2 weeks when stored at 5 °C.