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Stability and compatibility of anakinra with ceftriaxone sodium injection in 0·9% sodium chloride or 5% dextrose injection
Author(s) -
Nahata M. C.,
Morosco R. S.,
Sabados B. K.,
Weber T. R.
Publication year - 1997
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1046/j.1365-2710.1997.95275952.x
Subject(s) - anakinra , ceftriaxone , sodium , chemistry , medicine , chromatography , anesthesia , biochemistry , antibiotics , disease , organic chemistry
The stability and compatibility of anakinra (recombinant human interleukin‐1 receptor antagonist) with ceftriaxone sodium in 0·9% sodium chloride or 5% dextrose injection was determined during a 4‐h period at ambient room temperature and light. Anakinra was diluted in 0·9% sodium chloride or 5% dextrose to the concentrations of 4 and 36 mg/ml. Anakinra, at each concentration was mixed with ceftriaxone sodium (20 mg/ml) in a 50 : 50 proportion and stored in plastic culture vials with polypropylene caps. The samples were collected at 0, 2 and 4 h after mixing. Anakinra and ceftriaxone concentrations were measured using stability‐indicating HPLC methods. In 0·9% sodium chloride injection, the mean concentrations of anakinra and ceftriaxone exceeded 98% of initial concentrations at the end of the study period. In 5% dextrose, however, anakinra concentrations were below 90% of the expected initial concentration at the time of first analysis (within 0·5 h). Thus, anakinra appears to be stable and compatible with ceftriaxone sodium when diluted in 0·9% sodium chloride injection, but not in 5% dextrose injection over 4 h at ambient room temperature and light.