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The effect of paroxetine on thiothixene pharmacokinetics
Author(s) -
Guthrie S. K.,
Hariharan M.,
Kumar A. A.,
Bader G.,
Tandon R.
Publication year - 1997
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1046/j.1365-2710.1997.95175951.x
Subject(s) - paroxetine , medicine , pharmacokinetics , cyp2d6 , pharmacology , anesthesia , serotonin , cytochrome p450 , metabolism , receptor
Objective:In this study healthy volunteers received thiothixene with and without a 3‐day pretreatment with paroxetine to determine if paroxetine decreased the clearance of thiothixene. Method: Ten healthy medication‐free volunteers (4 women and 6 men, mean age 38±12 years) were randomized to receive a single 20 mg oral dose of thiothixene on two separate occasions. On one occasion thiothixene was given concurrently, and following 3 days of pre‐treatment with oral paroxetine (20 mg/day). On the other occasion thiothixene was given without paroxetine pre‐treatment. The two study days were separated by a minimum period of 2 weeks. On both study days, after the administration of thiothixene, 10 ml blood samples were collected over the next 72 h. Results: None of the pharmacokinetic parameters of thiothixene were significantly altered by a 3‐day treatment with paroxetine. Discussion: It is likely that the CYP2D6 isoenzyme is not responsible for a high proportion of thiothixene clearance, but one cannot exclude the possibility that a longer paroxetine pretreatment might have caused some inhibition of thiothixene clearance.