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Variations of teicoplanin concentrations in neutropenic patients
Author(s) -
Gimenez F.,
Leblond V.,
Nguyen J.,
Serrand P.,
Binet J. L.,
Grosset J.,
Thuillier A.
Publication year - 1997
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1046/j.1365-2710.1997.94375943.x
Subject(s) - teicoplanin , trough (economics) , trough concentration , medicine , bolus (digestion) , area under the curve , plasma concentration , neutropenia , trough level , pharmacology , anesthesia , pharmacokinetics , toxicity , vancomycin , biology , staphylococcus aureus , transplantation , macroeconomics , tacrolimus , bacteria , economics , genetics
The aim of this study was to measure the trough plasma concentrations of teicoplanin in neutropenic patients with a view to optimizing the loading dose. Teicoplanin trough plasma concentrations were followed in 11 neutropenic patients after repeated administration of a 6 mg/kg i.v. bolus. The first three injections were given at 12‐h intervals, and the rest every 24 h. Trough plasma concentrations at 48 h varied from 5·6 to 13·1 mg/l. The mean trough plasma concentration–time curve indicated a trend towards accumulation.In conclusion, the loading dose of teicoplanin should be tailored to individual neutropenic patients.