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Study protocol: stability of morphine injected without preservative, delivered with a disposable infusion device
Author(s) -
OustricMendes A.C.,
Huart B.,
Le Hoang M.D.,
PerrinRosset M.,
Pailler F.M.,
Darbord J.C.,
Prog P.,
Gard C.,
Pradeau D.
Publication year - 1997
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1046/j.1365-2710.1997.10475104.x
Subject(s) - preservative , morphine , medicine , anesthesia , protocol (science) , pharmacology , surgery , chemistry , food science , alternative medicine , pathology
Background and objective: Morphine hydrochloride, a major analgesic drug, is being increasingly administered using portable disposable infusion devices. The objective of this study was to investigate the stability of morphine in such a system at two concentrations (2·50 and 5·00 mg/ml) over a 30‐day period. Method : High‐performance liquid chromatography of stored morphine solutions. Results : The best stability was observed with disposable infusion devices filled with a morphine solution containing sodium metabisulphite as a preservative. No breakdown products were detected after 1 month of storage at room temperature, in light or darkness. On the other hand, 2·50 and 5·00 mg/ml morphine solutions without sodium metabisulphite, stored in the infusion device led to the formation of 0·205% and 0·235% of pseudomorphine, respectively, after 6 days of storage in the light, and 1·50% and 0·94% after 30 days storage. Conclusion : Morphine hydrochloride solutions stored in disposable infusion devices degraded very slowly, particularly when preserved with sodium metabisulphite. The solutions are stable over 5 days, the maximum period of storage normally required when using disposable infusers.