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In‐line filter occlusion during intravenous delivery of injectable menatetrenone (vitamin K 2 )
Author(s) -
Sendo T.,
Adachi K.,
Otsubo K.,
Aoyama T.,
Oishi R.
Publication year - 1996
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1046/j.1365-2710.1996.88875888.x
Subject(s) - emulsion , fat emulsion , filtration (mathematics) , electrolyte , chromatography , medicine , occlusion , chemistry , parenteral nutrition , biochemistry , mathematics , statistics , electrode
Filter occlusion during intravenous infusion of injectable menatetrenone in an electrolyte fluid was examined. The menatetrenone concentration and its emulsion droplet size were not changed by in‐line filtration. However, particle counts in the admixed solution and examination of scanning electron micrographs of the surface of the filter membrane indicated that particle formation occurred immediately after the admixture of menatetrenone injection with Hicaliq No. 2, but not with 5% glucose injection. This may be due to the interaction of excess lecithin in the emulsion with the electrolyte. Filter occlusion also occurred with the admixture of menatetrenone‐free emulsion and Hicaliq No. 2, but not with 5% glucose injection. These findings indicate that injectable menatetrenone should not be admixed with electrolyte fluids.