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In vitro activity of allicin against Staphylococcus epidermidis and influence of subinhibitory concentrations on biofilm formation
Author(s) -
PérezGiraldo C.,
CruzVillalón G.,
SánchezSilos R.,
MartínezRubio R.,
Blanco M.T.,
GómezGarcía A.C.
Publication year - 2003
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1046/j.1365-2672.2003.02030.x
Subject(s) - allicin , staphylococcus epidermidis , biofilm , microbiology and biotechnology , in vitro , bacteria , minimum inhibitory concentration , chemistry , biology , staphylococcus aureus , antimicrobial , biochemistry , genetics
Aims: The aim of this study is to determine the in vitro activity of allicin against Staphylococcus epidermidis and to evaluate the influence of allicin on biofilm formation. Methods and Results: In vitro activity of allicin (diallyl thiosulphinate) against 38 strains of S. epidermidis was investigated. The activity of allicin was similar against S. epidermidis methicillin susceptible and methicillin resistant strains [minimum inhibitory concentration (MIC) 90 = 8 mg l −1 ]. In general, subinhibitory concentrations (sub‐MIC) of allicin diminished biofilm formation in the five strains analysed. Conclusion: The results confirm the antibacterial effect of allicin. Sub‐MICs of allicin also diminished the biofilm formations by S. epidermidis . Significance and Impact of the Study: The present study shows that allicin is active in vitro against S. epidermidis and that sub‐MICs of allicin may play a role in the prevention of adherence of this bacteria to medical devices.