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Pathogenesis of enteric Campylobacter infection
Author(s) -
Van Vliet A.H.M.,
Ketley J.M.
Publication year - 2001
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1046/j.1365-2672.2001.01353.x
Subject(s) - campylobacter jejuni , campylobacter , virulence , microbiology and biotechnology , biology , pathogenesis , human pathogen , commensalism , immunology , bacteria , genetics , gene
1. S UMMARY Campylobacter jejuni and related species are important human pathogens, causing acute human enterocolitis, and they are the most common cause of food-borne diarrhoea in many industrialized countries. Previous infection with certain strains of C. jejuni is also linked with the develop- ment of the neurological disorder Guillain-Barresyndrome (GBS). Despite its importance as a human pathogen, relatively little is understood of the mechanisms of C. jejuni-associated disease. The recent release of the complete genome sequence of C. jejuni strain NCTC 11168, together with new strategies for random and directed mutagenesis, have allowed a better insight into some of the genetic determinants of C. jejuni virulence. In this review current knowledge on the pathogenesis of C. jejuni infection is summarized, and possible directions of future research indicated.