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Isolation of human faecal bifidobacteria which reduce signs of Salmonella infection when orogastrically dosed to mice
Author(s) -
Henriksson A.,
Conway P.L.
Publication year - 2001
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1046/j.1365-2672.2001.01238.x
Subject(s) - isolation (microbiology) , salmonella , microbiology and biotechnology , feces , biology , salmonella infection , enterobacteriaceae , bacteria , escherichia coli , biochemistry , genetics , gene
A. HENRIKSSON AND P.L. CONWAY. 2001 . Aims: The aim of the study was to isolate human bifidobacteria that inhibit growth of Salmonella typhimurium in vitro , and provide protection against Salmonella infection in mice. Methods and Results: A total of 92 micro‐organisms, which displayed antagonist activity against Salm. typhimurium in vitro , were isolated from human faecal material. Based on their Gram stain status, cultures were pooled and tested for anti‐ Salmonella activity. The Gram‐variable group was the most active. From that group, three bifidobacteria (Lafti™B22, B74 and B97) individually showed good pathogen inhibition in vivo . Conclusions: Oral administration of certain human bifidobacteria provides protection against Salmonella infection in mice. Significance and Impact of the Study: These results indicate that certain bifidobacteria may be used as a prophylaxis for reduced incidence and severity of Salmonella infections.