Premium
Characterization and mechanism of action of cerein 7, a bacteriocin produced by Bacillus cereus Bc7
Author(s) -
Oscáriz J.C.,
Pisabarro A.G.
Publication year - 2000
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1046/j.1365-2672.2000.01123.x
Subject(s) - bacillus cereus , bacteriocin , bacteria , cereus , microbiology and biotechnology , bacillales , biology , antibacterial activity , mode of action , gram negative bacteria , molecular mass , bacillus (shape) , gram positive bacteria , bacillaceae , antibiotics , chemistry , biochemistry , antimicrobial , escherichia coli , enzyme , bacillus subtilis , genetics , gene
Cerein 7 is a peptidic antibiotic produced by Bacillus cereus Bc7 (CECT 5148) at the end of exponential growth but before sporulation onset. Cerein 7 has a broad spectrum of antibacterial activity against Gram‐positive bacteria, but it is inactive against Gram‐negative bacteria. The sequence of its amino‐terminal end and its characteristics of hydrophobicity and molecular mass make cerein 7 unique among the bacteriocins produced by the soil bacterium B. cereus . In this paper a further characterization of cerein 7 is presented, it is shown that it can be classified as a Klaenhammer's class II bacteriocin and that its mode of action corresponds to that of a membrane‐active compound.