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The response of Aeromonas hydrophila to oxidative stress induced by exposure to hydrogen peroxide
Author(s) -
Landre J.P.B.,
Gavriel A.A.,
Rust R.C.,
Lamb A.J.
Publication year - 2000
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1046/j.1365-2672.2000.01090.x
Subject(s) - aeromonas hydrophila , hydrogen peroxide , oxidative stress , microbiology and biotechnology , biology , population , virulence , pathogen , bacteria , genetics , biochemistry , gene , medicine , environmental health
Aeromonas hydrophila , an opportunist human pathogen of low virulence, was shown to display a high degree of sensitivity upon exposure to hydrogen peroxide. As with other species, Aer. hydrophila is able to develop the capacity to resist loss of viability induced by such oxidative stress. Development of stress resistance follows the archetypal profile where pre‐exposure of a population to sub‐lethal levels of H 2 O 2 stimulates onset of tolerance to further exposure. Acquisition of tolerance critically requires nascent protein synthesis. Further analysis demonstrated population growth phase influences the degree of sensitivity of the organism. Late stationary phase cultures demonstrate a decreased sensitivity compared with younger populations. Significantly, it was also determined that stock culture age influenced the level of sensitivity of the derived experimental culture, where an increased stock culture age corresponded with enhanced resistance to H 2 O 2 . These data show that Aer. hydrophila population phenotype is influenced by the phenotype of the donor stock culture.