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Human immune responses to the UK human anthrax vaccine
Author(s) -
Baillie L. W. J.,
Fowler K.,
Turnbull P. C. B.
Publication year - 1999
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1046/j.1365-2672.1999.00899.x
Subject(s) - subclass , anthrax vaccines , immunology , immune system , antibody , biology , virology , immunity , antigen , antibody response , humoral immunity , immunoglobulin g , microbiology and biotechnology , immunization , dna vaccination
The IgG anti‐protective antigen subclass antibody response of individuals who had been infected with anthrax was compared with that of healthy individuals immunized with the UK licensed anthrax vaccine. The predominant subclass in both groups was IgG1. In addition, IgG3 was seen in convalescent serum while vaccinees produced IgG2, IgG3 and IgG4 subclass. The significance of these results is discussed. Further work is required to determine the role of antibodies in mediating protective immunity in man.