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Lacticin 3147 displays activity in buffer against Gram‐positive bacterial pathogens which appear insensitive in standard plate assays
Author(s) -
Galvin M.,
Hill C.,
Ross R. P.
Publication year - 1999
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1046/j.1365-2672.1999.00550.x
Subject(s) - gram , microbiology and biotechnology , biology , bacteria , gram negative bacteria , escherichia coli , genetics , gene
Lacticin 3147 is a broad‐spectrum bacteriocin produced by Lactococcus lactis subsp. lactis DPC3147, which has been shown to be active against a range of food‐borne bacteria. The reported inhibitory range for lacticin is extended to include methicillin‐resistant Staphylococcus aureus , vancomycin‐resistant Enterococcus faecalis , penicillin‐resistant Pneumococcus, Propionibacterium acne and Streptococcus mutans . This extended host range is not obvious from traditional agar plate‐based methods, but reductions in bacterial cell numbers by up to 6 log 10 cfu ml −1 was observed after 2 h in time‐kill curve studies conducted in broth, suggesting that the bacteriocin may have potential as a therapeutic agent in the treatment of human infections.