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Effect of permeabilizers on antibiotic sensitivity of Pseudomonas aeruginosa
Author(s) -
Ayres H. M.,
Furr J. R.,
Russell A. D.
Publication year - 1999
Publication title -
letters in applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.698
H-Index - 110
eISSN - 1472-765X
pISSN - 0266-8254
DOI - 10.1046/j.1365-2672.1999.00486.x
Subject(s) - novobiocin , pseudomonas aeruginosa , antibiotics , gentamicin , microbiology and biotechnology , vancomycin , chemistry , erythromycin , rifampicin , bacteria , antibacterial agent , biology , staphylococcus aureus , genetics
Agents which had previously been shown to act as permeabilizers against Pseudomonas aeruginosa or other Gram‐negative bacteria were tested to determine whether susceptibility to various antibiotics could be increased. In the absence of a permeabilizer, Ps. aeruginosa was resistant to several hydrophobic antibiotics and vancomycin, but not to gentamicin. Tartaric and gluconic acids had weak potentiating activity, whereas ethylenediamine tetraacetic acid and citric acid were more effective permeabilizers. However, sodium polyphosphate enhanced the activity of erythromycin, fucidin, novobiocin, rifampicin and methicillin ; vancomycin was unaffected and the activity of gentamicin was reduced considerably.