Premium
Ecomycins, unique antimycotics from Pseudomonas viridiflava
Author(s) -
Christopher M. Miller,
Russell Miller,
D Garton-Kenny,
B Redgrave,
Joseph Sears,
Margaret M. Condron,
David B. Teplow,
Gary A. Strobel
Publication year - 1998
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1046/j.1365-2672.1998.00415.x
Subject(s) - biology , glycine , microbiology and biotechnology , biochemistry , pseudomonas , cryptococcus neoformans , alanine , lipopeptide , bacteria , amino acid , genetics
A novel family of peptide antimycotics, termed ecomycins, is described from Pseudomonas viridiflava , a plant‐associated bacterium. Ecomycins B and C have molecular masses of 1153 and 1181. They contain equimolar amounts of a β hydroxyaspartic acid, homoserine, threonine, serine, alanine, glycine and one unknown amino acid. Fatty acids were detectable after hydrolysis, methylation and gas chromatography and mass spectroscopy. The ecomycins have significant bioactivities against a wide range of human and plant pathogenic fungi. The minimum inhibitory concentration values for ecomycin B were 4·0 μg ml −1 against Cryptococcus neoformans and 31 μg ml −1 against Candida albicans. Pseudomonas viridiflava also produces what appears to be syringotoxin, an antifungal lipopeptide previously described from Ps. syringae.